Makes adderall effect stronger (experiment by taking less adderall when you take nicotine) Beverages that contain caffeine like coffee, tea and those carbohydrate drinks like soda should be avoided completely while taking adderall. Is It Safe To Mix Adderall And Coffee Is an hour considered enough time before and/or after taking the meds to avoid the absorption blocking? Coffee and adderall absorption . It has diuretic properties that could shorten the lifespan of adderall by prompting the body to remove the drug from its system sooner. So essentially you are intensifying the remaining 1/2 dose of xr in your system, but also you are going to metabolize it faster, and pee it out sooner. If you drink coffee, which is an acidic drink, it will cause the bioavailability of adderall to decrease. This is not advised and can be dangerous, leading to a possible adderall overdose. Coffee could also reduce the effectiveness of adderall. The absorption of adderall depends upon the ph ...